Publicações

Laboratório de Química Bio-Orgânica Otto Richard Gottlieb

1) Bou, D. D.; Santos, A. L.; Figueiredo, C. R.; Farias, C. F.; Matsuo, A. L.; Kitamura, R. O. S.; Gimenes, L.; Lago, J. H. G.; Sartorelli, P. Dinor casearin X – A new cytotoxic clerodane Dinor diterpene from Casearia sylvestris. Journal of the Brazilian Chemical Society, v. 26, p. 1725-1729, 2015. DOI number: 10.5935/0103-5053.20150128

2) Andersen, A.; De Medeiros, L. S.; Binzer, S.; Rasmussen, S. A.; Hansen, P. J.; Nielsen, K. F.; Jørgensen, K.; Larsen, T. O. HPLC-HRMS quantification of the ichthyotoxin karmitoxin from Karlodinium armiger. Marine Drugs, v. 15, p. 278, 2017. DOI number: 10.3390/md15090278

3) Ferreira-Silva, G. A.; Lages, C. C. L.; Sartorelli, P.; Hasegawa, F. R.; Soares, M. G.; Ionta, M. Casearin D inhibits ERK phosphorylation and induces downregulation of cyclin D1 in HepG2 cells. Toxicology in vitro, v. 38, p. 27-32, 2017. DOI number: 10.1016/j.tiv.2016.10.011

4) Rasmussen, S. A.; Binzer, S. B.; Hoeck, C.; Meier, S.; De Medeiros, L. S.; Andersen, N. G.; Place, A.; Nielsen, K. F.; Hansen, P. J.; Larsen, T. O. Karmitoxin – An amine-containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger. Journal of Natural Products, v. 1, 2017. DOI number: 10.1021/acs.jnatprod.6b00860

5) Santos, A. L.; Yamamoto, E. S.; Laurenti, M. D.; Martins, L. F.; Lima, M. L.; Uemi, M.; Soares, M. G.; Passero, L. F. D.; Lago, J. H. G.; Tempone, A. G.; Sartorelli, P. Antileishmanial activity and immunomodulatory effects of constituents from leaves of Casearia arborea (Salicaceae). Chemistry and Biodiversity , v. 4, 5, e-1600458, 2017. DOI number: 10.1002/cbdv.201600458

6) Caldas, L. A.; Horvath, R. O.; Ferreira-Silva, G. A.; Ferreira, M. J. P.; Ionta, M.; Sartorelli, P. Calein C, a sesquiterpene lactone isolated from Calea pinnatifida (Asteraceae), inhibits mitotic progression and induces apoptosis in MCF-7 cells. Frontiers in Pharmacology, v. 9, article 1191, 2018. DOI number: 10.3389/fphar.2018.01191

7) Caldas, L. A.; Yoshinaga, M. L.; Ferreira, M. J. P.; Lago, J. H. G.; Souza, A. B.; Laurenti, M. D.; Passero, L. F. D.; Sartorelli, P. Antileishmanial activity and ultrastructural changes of sesquiterpene lactones isolated from Calea pinnatifida (Asteraceae). Bioorganic Chemistry, v. 83, p. 348-353, 2019. DOI number: 10.1016/j.bioorg.2018.10.059

8) De Carvalho, A. C.; Girola, N.; Figueiredo, C. R.; Machado, A. C. ; Medeiros, L. S.; Guadagnin, R. C.; Caseli, L.; Veiga, T. A. M. Understanding the cytotoxic effects of new isovanillin derivatives through phospholipid langmuir monolayers. Bioorganic Chemistry, v. 83, p. 205-213, 2019. DOI number: 10.1016/j.bioorg.2018.10.029

9) Din, Z. U.; De Medeiros, L. S.; Abreu, L. M.; Pfenning, L.; Jymeni, D. B. L.; Rodrigues-Filho, E. Differential metabolism of diastereoisomeric diterpenes by Preussia minima, found as endophytic fungus in Cupressus lusitanica. Bioorganic Chemistry, v. 78, p. 436-443, 2018. DOI number: 10.1016/j.bioorg.2018.04.003

10) Din, Z. U.; Trapp, M. A.; De Medeiros, L. S.; Lazarin-Bidóia, D.; Garcia, F. P.; Peron, F.; Nakamura, C. V.; Rodríguez, I. C.; Wadood, A.; Rodrigues-Filho, E. Symmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds. European Journal of Medicinal Chemistry, v. 155, p. 596, 2018. DOI number: 10.1016/j.ejmech.2018.06.031

11) Hansen, C. I. .C.; Sørensen, M.; Veiga, T. A. M. ; Zibrandtsen, J. F. S.; Heskes, A. M.; Olsen, C. E.; Boughton, B. A.; Møller, B. L.; Neilson, E. H. J. Reconfigured cyanogenic glucoside biosynthesis in Eucalyptus cladocalyx involves a cytochrome p450 cyp706c55. Plant Physiology, v. 178, p. 1081–1095, 2018. DOI number: 10.1104/pp.18.00998

12) Kildgaard, S.; De Medeiros, L. S.; Phillips, E.; Gotfredsen, C. H.; Frisvad, J. C.; Nielsen, K. F.; Abreu, L. M.; Larsen, T. O. Cyclopiamines C and D – Epoxide Spiroindolinone alkaloids from Penicillium sp. CML 3020. Journal of Natural Products, v. 81, p. 785–790, 2018. DOI number: 10.1021/acs.jnatprod.7b00825

13) Sampaio, O. M.; Vieira, L. C. C.; Bellete, B. S.; King-Díaz, B.; Lotina-Hennsen, B.; da Silva,  M. F. G. F.; Veiga, T. A. M. Evaluation of alkaloids isolated from Ruta graveolens as photosynthesis inhibitors. Molecules, v. 23, p. 2693, 2018. DOI number: 10.3390/molecules23102693

14) Vital, W. D.; Torquato, H. F. V.; Jesus, L. O. P.; Judice, W. A. S.; Silva, M. F. G. F.; Rodrigues, T.; Justo, G. Z.; Veiga, T. A. M.; Paredes-Gamero, E. J. 4-deoxyraputindole C induces cell death and cell cycle arrest in tumor cell lines. Journal of Cellular Biochemistry, p. 1-16, 2018. DOI number: 10.1002/jcb.28238

15) De Carvalho, A. C.; Lira, J. C. S.; Pereira, T. M.; Silva, S. C.; Simote-Silva, S. Y.; Oliveira, F. K. D.; King-Diaz, B.; Lotina-Hennsen, B.; Veiga, T. A. M. Natural products from Pluchea sagittalis act as inhibitors of photosynthesis in vitro. Natural Products Research, v. 83, p. 557-562, 2019. DOI number: 10.1080/14786419.2017.1396587

16) Dantas, E.; Monteiro, J.; De Medeiros, L.; Romanelli, M.; Amaral, M.; Tempone, A.; Lago, J. H.; Soares, M.; Sartorelli, P. Dereplication of aporphine alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Duguetia lanceolata St.-Hil (Annonaceae) and antiparasitic activity evaluation. Journal Of The Brazilian Chemical Society, v. 31, p. 1-9, 2020. DOI number: 10.21577/0103-5053.20200089

17) De Carvalho, A. C.; Rodrigues, L. De C.; Ribeiro, A. I.; Da Silva, M. F. Das G. F.; De Medeiros, L. S.; Veiga, T. A. M. Integrated analytical tools for accessing acridones and unrelated phenylacrylamides from Swinglea glutinosa. Molecules, v. 25, p. 153, 2020. DOI number: 10.3390/molecules25010153

18) De Carvalho, A. C.; Ogawa, C. Y.; Rodrigues, L. De C.; De Medeiros, L. S.; Veiga, T. A. M. Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020. Leukemia & Lymphoma, v. 1, p. 1-15, 2021. DOI number: 10.1080/10428194.2021.1897804

19) Polassi, M. R.; Oliveira, T. S.; Carvalho, A.; De Medeiros, L. S.; Veiga, T.; Graeff, C. F. O.; Gonzalez, A. H. M.; Marcucci, M. C.; Grecco, S.; Dalpino, P. H. P. Influence of dentin priming with tannin-rich plant extracts on the longevity of bonded composite restorations. The Scientific World Journal, v. 2021, p. 1-9, 2021. DOI number: 10.1155/2021/1614643

20) Santos, A. L.; Ionta, M.; Horvath, R.; Soares, M. G.; De Medeiros, L. S.; Uemi, M.; Kawafune, E. S.; Tangerina, M. M. P.; Ferreira, M. J. P.; Sartorelli, P. Molecular network for accessing polyketide derivatives from Phomopsis sp., an endophytic fungus of Casearia arborea (Salicaceae). Phytochemistry Letters, v. 42, p. 1-7, 2021. DOI number: 10.1016/j.phytol.2020.11.020

21) Santos, A. L.; Soares, M. G.; De Medeiros, L. S.; Ferreira, M. J. P.; Sartorelli, P. Identification of flavonoid‐3‐O‐glycosides from leaves of Casearia arborea (Salicaceae) by UHPLC‐DAD‐ESI‐HRMS/MS combined with molecular networking and NMR. Phytochemical Analysis On Line, v. 31, p. 1, 2021. DOI number: 10.1002/pca.3032

22) Marcucci, M. C.; Oliveira, C. R.; Spindola, D.; Antunes, A. A.; Santana, L. Y. K.; Cavalaro, V.; Costa, I. B.; De Carvalho, A. C.; Veiga, T. A. M.; Medeiros, L. S.; Zamarioli, L. Dos S.; Gonçalves, C. P.; Santos, M. F.; Grecco, S. S.; Suzuki, V. Y.; Ferreira, L. M.; Garcia, D. M. Molecular dereplication and in vitro and in silico pharmacological evaluation of Coriandrum sativum against neuroblastoma cells. Molecules, v. 27, p. 5389, 2022. DOI number: 10.3390/molecules27175389

23) De Carvalho, A. C.; Lima, C. S.; Torquato, H. F. V.; Domiciano, A. T.; Silva, S. Da C.; De Abreu, L. M.; Uemi, M.; Paredes-Gamero, E. J.; Vieira, P. C.; Veiga, T. A.; De Medeiros, L. S. Chemodiversity and anti-leukemia effect of metabolites from Penicillium setosum CMLD 18. Metabolites, v. 13, p. 23, 2023. DOI number: 10.3390/metabo13010023

24) Marinho, A. M. Do R.; De Oliveira, C. M. S. C.; Silva-Silva, J. V.; De Jesus, S. C. A.; Siqueira, J. E. S.; De Oliveira, L. C.; Auzier, J. F.; Soares, L. N.; Pinheiro, M. L. B.; Silva, S. C.; Medeiros, L. S.; Costa, E. V.; Marinho, P. S. Barbosa. Antimicrobial activity and molecular docking studies of the biotransformation of diterpene acanthoic acid using the fungus Xylaria sp.. Antibiotics-Basel, v. 12, p. 1331, 2023. DOI number: 10.3390/antibiotics12081331

25) Peres, E.; Souza, M.; Sousa, T.; Da Silva, C.; Barros, A.; Da Silva, F.; Costa, E.; De Medeiros, L. S.; Forim, M.; De Souza, A.; Paz, W.; Da Silva, G.; De Souza, A.; Koolen, H. Dereplication of sclerotiorin-like azaphilones produced by Penicillium meliponae using LC-MS/MS analysis and molecular networking. Journal Of The Brazilian Chemical Society, v. 34, p. 1/00-15, 2023. DOI number: 10.21577/0103-5053.20230027

26) Sousa, T. F.; Júnior, M. B. De A.; Peres, E. G.; Souza, M. P.; Da Silva, F. M. A.; De Medeiros, L. S.; De Souza, A. D. L.; De Souza, A. Q. L.; Yamagishi, M. E. B.; Da Silva, G. F.; Koolen, H. H. F.; De Queiroz, M. V. Discovery of dual PKS involved in sclerotiorin biosynthesis in Penicillium meliponae using genome mining and gene knockout. Archives Of Microbiology, v. 205, p. 1, 2023. DOI number: 10.1007/s00203-023-03414-1

27) Adrião, A.; Da Silva, C.; Araujo, M.; Paz, W.; De Medeiros, L. S.; Da Silva, F.; Bezerra, D.; Salimo, Z.; Monteiro, W.; De Melo, G.; Costa, E.; Tavares, J.; Koolen, H. Annotation of alkaloids of Fusaea longifolia and evaluation of anti-plasmodium activity in vitro and in silico. Journal Of The Brazilian Chemical Society, v. 35, p. 1-12, 2024. DOI number: 10.21577/0103-5053.20240016

28) Anselmo, L. T.; De Souza, T. A.; Brito, T. A. M.; Peres, E. G.; Da Silva, F. M. A.; Silva, V. R.; Santos, L. De S.; Soares, M. B. P.; Bezerra, D. P.; Costa, E. V.; Sipoloni, Victor M.; De Medeiros, L. S.; Da Silva, M. S.; Tavares, J. F.; Gomes, W. R.; Koolen, H. H. F. Pleonotoquinones, cytotoxic Oxepinenaphthoquinones from Pleonotoma jasminifolia. Journal Of Natural Products, v. 87, p. 1217-1221, 2024. DOI number: 10.1021/acs.jnatprod.3c01191

29) Cassas, F.; Dos Reis, V. E. N.; Cardoso, C. L.; De Assis, L. T.; Cass, Q. B.; Uemi, M.; Vieira, P. C.; Barretto, E. H. P.; De Medeiros, L. S.; Veiga, T. A. M. Unveiling new myrsinoic acids and AChE ligands from Myrsine guianensis (Aubl.) Kuntze. Fitoterapia, v. 175, p. 105972, 2024. DOI number: 10.1016/j.fitote.2024.105972

30) Da Silva, C. V. A.; Salimo, Z. M.; De Souza, T. A.; Reyes, D. E.; Bassicheto, M. C.; De Medeiros, L. S.; Sartim, M. A.; De Carvalho, J. C.; Gonçalves, J. F. C.; Monteiro, W. M.; Tavares, J. F.; De Melo, G. C.; Da Silva, F. M. A.; Bataglion, G. A.; Koolen, H. H. F. Cupuaçu (Theobroma grandiflorum): A multifunctional Amazonian fruit with extensive benefits. Food Research International, v. 1, p. 114729, 2024. DOI number: 10.1016/j.foodres.2024.114729

31) Fonseca, A. M.; Dos Santos, R. G.; De Medeiros, L. S.; Veiga, T. A. M.; Cassas, F.; Bruniera, C. P.; Rossi, G. N.; Bouso, J. C.; Hallak, J. E. C.; Santos, F. P.; Paranhos, B. A. P. B.; Yonamine, M.; Rodrigues, E. Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users. European Archives Of Psychiatry And Clinical Neuroscience, p. 1, 2024. DOI number: 10.1007/s00406-024-01817-9

32) Lopes, I. S.; S., J. K. C.; De Medeiros, L. S.; Courrol, L. C. Evaluation of ALA-capped silver, copper, and silver-copper nanoparticles for controlling fungal plant pathogens. Microbial Pathogenesis, v. 191, p. 106672, 2024. DOI number: 10.1016/j.micpath.2024.106672

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